Synthesis of [3H]-VUF 4576; A new radiolabelled Ca2+-antagonist

✍ Scribed by P. Caldirola; H. Timmerman

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: French
• Weight: 344 KB
• Volume: 31
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580311205

✦ Synopsis

Abstract

The new radiolabelled [^3^H]‐VUF 4576 has been prepared by an easy procedure using commercially available C^3^H~3~I. The new radiolabelled ligand [^3^H]‐VUF 4576 belongs to a subclass of prenylamine analogues which interfere with calcium regulated pathways. The compound has been synthesized in order to study the interaction of other compounds with these mechanisms and in particular the site of action of this subclass of calcium entry blockers and calmodulin antagonists.