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Synthesis of 14C-labelled Cefluprenam (E1077), a novel parenteral cephalosporin antibiotic

✍ Scribed by Nobuaki Sato; Yasunobu Kai; G. I. Shemilt; Shigeru Chiku

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
214 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Cefluprenam (E1077) is a new parenteral cephalosporin with a well‐balanced antibacterial spectrum and potent antibacterial activity. It was synthesized labelled in the side chain at the 3‐position of the cephem with carbon‐14, starting from potassium [^14^C]cyanide, according to the method illustrated in Schemes 1,2. [^14^C]Cefluprenam having a specific activity of 3.9 MBq/mg, was obtained in 28.6 % overall radiochemical yield, with a radiochemical purity of more than 97.3 %.

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