Synthesis of a Racemic Ester and Its Lipase-Catalyzed Kinetic Resolution
β Scribed by Stetca, Delia; Arends, Isabel W. C. E.; Hanefeld, Ulf
- Book ID
- 120502389
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 69 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0021-9584
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π SIMILAR VOLUMES
Optically active 3-, 4-, 5-, or 6-methyl substituted seven-membered lactones were prepared by Candida antarctica lipase (CAL)-catalyzed kinetic resolution of the racemic lactones. Among these lactones, only in the case of 5-methylhexanolide (R)-isomer reacts faster than the other enantiomer, while t
Racemic amino acids were resolved by lipase via hydrolysis of their esters. Lipases (Pseudomonas lipase from Amano PS, Rhizopus lipase from Serva, and porcine pancrease lipase from Sigma) could selectively hydrolyze the L-amino acid esters in aqueous solution with high reactivities and selectivities