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Synthesis of a potential enzyme-specific inhibitor of squalene synthase

โœ Scribed by A. R. P. M. Valentijn; R. de Haan; S. Hagens; E. de Kant; G. A. van der Marel; L. H. Cohen; J. H. van Boom

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
508 KB
Volume
114
Category
Article
ISSN
0165-0513

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โœ C.H. Kuo; S.P. Plevyak; T. Biftu; W.H. Parsons; G.D. Berger ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 258 KB

The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11