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Synthesis of a potential antiviral compound: 5-bromoethynyl-2′-deoxyuridine

✍ Scribed by Kurt Eger; Mohammad Jalalian; Mathias Schmidt

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
591 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

Abstra& 5-Btcmoethynylmcil and its deoxyriboside cau be prepared io good yields starting from dibromovinyluracil, which is accesible by litfmtm mehds. S-Btumaethynyl-deox~ is less eikxive against HSV-1 than E-~cwitty0-deox~ but, similar to BVDU, seems to exhibit a certain nelectivity toward HSV-1. Molemlat cxhlations Ptove tbe spatial simihity of both cuqotmds.

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