Synthesis of a polymer-supported sialic acid glycosyl donor
β Scribed by Leonid O. Kononov; Yukishige Ito; Tomoya Ogawa
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 221 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A sialic acid glycosyl donor 9 immobilized on polyethyleneglycol monomethyl ether (MPEG) was prepared. Glycosylation of galactose derivatives 10 or 15 with 9 led to oc-linked disaccharides 13 and 16, respectively.
π SIMILAR VOLUMES
5-Azido sialyl donors with O-acetyl protecting groups are useful Ξ±-selective glycosylation reagents, especially for primary hydroxyl groups as acceptors. This is shown with a variety of reactions using 1 as a sialyl donor. It was also possible to synthesize NeuAcΞ±(2β9)NeuAc as a thioglycoside donor
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