The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the α-Glycosylation of Primary Hydroxy Groups
✍ Scribed by Chung-Shan Yu; Kenichi Niikura; Chun-Cheng Lin; Chi-Huey Wong
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 112 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0044-8249
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✦ Synopsis
5-Azido sialyl donors with O-acetyl protecting groups are useful α-selective glycosylation reagents, especially for primary hydroxyl groups as acceptors. This is shown with a variety of reactions using 1 as a sialyl donor. It was also possible to synthesize NeuAcα(2→9)NeuAc as a thioglycoside donor for use in subsequent glycosylations.
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