A sialic acid glycosyl donor 9 immobilized on polyethyleneglycol monomethyl ether (MPEG) was prepared. Glycosylation of galactose derivatives 10 or 15 with 9 led to oc-linked disaccharides 13 and 16, respectively.
Sialic Acid Donors: Chemical Synthesis and Glycosylation
β Scribed by Dino K. Ress; Robert J. Linhardt
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 48 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
5-Azido sialyl donors with O-acetyl protecting groups are useful Ξ±-selective glycosylation reagents, especially for primary hydroxyl groups as acceptors. This is shown with a variety of reactions using 1 as a sialyl donor. It was also possible to synthesize NeuAcΞ±(2β9)NeuAc as a thioglycoside donor
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