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Synthesis of a phosphonate isostere of ganciclovir monophosphate: A highly cytomegalovirus active phosphonate nucleotide analogue

✍ Scribed by Choung Un Kim; Peter F Misco; Bing Y Luh; John C Martin

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
223 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel synthetic methodology for the hydroxymethyl substituted acyclic acetal functionality was developed. The rationally designed phosphonate analogue 3 of ganciclovir monophosphate was highly active against human cytomegalovirus.

Ganciclovir ( ) is an exceptionally potent agent against herpesviruses 1-3 and has been approved for the treatment of cytomegalovirus retinitis. As the essential

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