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Highly enantioselective hydrogenation of α,β-unsaturated phosphonates with iridium–phosphinooxazoline complex: synthesis of a phosphorus analogue of naproxen

✍ Scribed by Natalia S Goulioukina; Tat'yana M Dolgina; Grigorii N Bondarenko; Irina P Beletskaya; Mikhail M Ilyin; Vadim A Davankov; Andreas Pfaltz

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
156 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

A number of pharmaceutically interesting optically active 1-arylethylphosphonates, including a phosphorus analogue of naproxen, has been synthesized with ee 92-95% via asymmetric hydrogenation under mild conditions using [Ir(cod)(phosphine oxazoline)] + [BAr F ] -catalysts.

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