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Synthesis and Phosphodiesterase 5 Inhibitory Activity of New Sildenafil Analogues Containing a Phosphonate Group in the 5′-Sulfonamide Moiety of Phenyl Ring.

✍ Scribed by Dae-Kee Kim; Ju Young Lee; Hyun-Ju Park; Khac Minh Thai


Publisher
John Wiley and Sons
Year
2004
Weight
86 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract The synthesis of a novel ring‐expanded nucleoside analogue, (Z)‐1‐((2‐Guanidinocarbamoyl‐cyclopropylidene)methyl)‐4,5,7,8‐tetrahydro‐6__H__‐6‐iminoimidazo[4,5‐__e__][1,3]diazepine‐4,8‐dione (**1**) has been reported. It was prepared starting from methyl imidazole‐4,5‐dicarboxylate by se