𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of a peptidyl 2,2-difluoro-4-phenylbutyl ketone and its evaluation as an inhibitor of interleukin-1β converting enzyme.

✍ Scribed by Adnan M.M. Mjalli; Kevin T. Chapman; Malcolm MacCoss


Book ID
108476998
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
303 KB
Volume
3
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


A one-step synthesis of ethyl 4-(β-indol
✍ David G. Hangauer Jr. 📂 Article 📅 1981 🏛 Elsevier Science 🌐 French ⚖ 176 KB

The trianion of 3-(S-indolyl)-propionic acid was condensed with diethyl oxalate to give ethyl 4-(B-indolyl)-2-ketobutyrate which, upon coupling with various dipeptides, gave potent angiotensin converting enzyme inhibitors. Recently, a-anions of carboxylate salts have become viable synthonsl. Such