✦ LIBER ✦
A one-step synthesis of ethyl 4-(β-indolyl)-2-ketobutyrate via polyanion chemistry and its conversion into angiotensin converting enzyme inhibitors
✍ Scribed by David G. Hangauer Jr.
- Book ID
- 104244042
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 176 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The trianion of 3-(S-indolyl)-propionic acid was condensed with diethyl oxalate to give ethyl 4-(B-indolyl)-2-ketobutyrate which, upon coupling with various dipeptides, gave potent angiotensin converting enzyme inhibitors.
Recently, a-anions of carboxylate salts have become viable synthonsl.
Such dianions have