Synthesis of a novel tetrapyrrolic macrolactam and its activity towards Uro'gen III synthase

✍ Scribed by Clotilde Pichon; A. Ian Scott

• Book ID: 104589802
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 869 KB
• Volume: 115
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19961150102

✦ Synopsis

Abstract

A novel macrocyclic tetrapyrrolelactam 8, analog of a putative intermediate, has been synthesized. Its very low inhibitory effect on Uro'gen III synthase renders it unlikely to be a low‐energy transition‐state analog.