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ChemInform Abstract: Synthesis of a Novel Tetrapyrrolic Macrolactam (X) and Its Activity Towards Uro′gen III Synthase.

✍ Scribed by C. PICHON; A. I. SCOTT


Book ID
112032132
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of a novel tetrapyrrolic macro
✍ Clotilde Pichon; A. Ian Scott 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 869 KB

## Abstract A novel macrocyclic tetrapyrrolelactam 8, analog of a putative intermediate, has been synthesized. Its very low inhibitory effect on Uro'gen III synthase renders it unlikely to be a low‐energy transition‐state analog.