✦ LIBER ✦

Synthesis of a novel series of 6-chloro-1,4,2-benzodithiazine 1,1-dioxide derivatives with potential biological activity

✍ Scribed by Z. Brzozowski; F. Sa̧zewski

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 178 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420708

No coin nor oath required. For personal study only.

✦ Synopsis

A novel series of 6-chloro-1,4,2-benzodithiazine 1,1-dioxide derivatives 2-19 with alkyl, aryl or heteroaryl substituents at position 3 have been synthesized by the reaction of 4-chloro-2-mercaptobenzenesulfonamides with aldehydes, aldehyde acetals or acid anhydrides. 6-Chloro-3-(2-hydroxyphenyl)-7-methyl-2,3-dihydro-1,4,2-benzodithiazine 1,1-dioxide ( 7) exhibited remarkable activity on the leukemia CCRF-CEM cell line (GI 50 <10 nM) and moderate activity against the other 49 human tumor cell lines derived from nine different cancer type.

📜 SIMILAR VOLUMES

Synthesis of a Novel Series of 6-Chloro-

Synthesis of a Novel Series of 6-Chloro-1,4,2-benzodithiazine 1,1-Dioxide Derivatives with Potential Biological Activity.

✍ Z. Brzozowski; F. Saczewski 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Synthesis and anti-HIV-1 Activity of a N

Synthesis and anti-HIV-1 Activity of a Novel Series of 1,4,2-Benzodithiazine-dioxides.

✍ Zdzislaw Brzozowski; Franciszek Saczewski; Nouri Neamati 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views

Synthesis and in vitro Cytotoxic Activit

Synthesis and in vitro Cytotoxic Activity of Novel 6-Chloro-1,1-dioxo-1,4,2-benzodithiazin-3-ylhydrazine Derivatives.

✍ E. Pomarnacka; P. J. Bednarski; R. Grunert; Z. Brzozowski; J. Lach 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

Synthesis, Cytotoxicity Testing, and Str

Synthesis, Cytotoxicity Testing, and Structure–Activity Relationships of Novel 6-Chloro-7-(4-phenylimino-4H-3,1-benzoxazin-2-yl)-3-(substituted)-1,4,2-benzodithiazine 1,1-dioxides

✍ Elżbieta Pomarnacka; Anita Kornicka; Anna Kuchnio; Maike Heinrichs; Renate Grüne 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB 👁 2 views

## Abstract A new series of 16 6‐chloro‐1,1‐dioxo‐7‐{4‐[(4‐R^1^‐phenyl)imino]‐4__H__‐3,1‐benzoxazin‐2‐yl}‐3‐(substituted amino)‐1,4,2‐benzodithiazines **7–22** was prepared in order to evaluate the cytotoxic activity against six human cancer cell lines. The structures of the new compounds were conf

Synthesis of 8-Chloro-5,5-dioxo[1,2,4]tr

Synthesis of 8-Chloro-5,5-dioxo[1,2,4]triazolo[4,3-b][1,4,2]benzodithiazine Derivatives with Potential Anticancer and anti-HIV-1 Activities.

✍ Z. Brzozowski; F. Saczewski 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

ChemInform Abstract: Synthesis, Cytotoxi

ChemInform Abstract: Synthesis, Cytotoxicity Testing, and Structure—Activity Relationships of Novel 6-Chloro-7-(4-phenylimino-4H-3,1-benzoxazin-2-yl)-3- (substituted)-1,4,2-benzodithiazine 1,1-Dioxides.

✍ Elzbieta Pomarnacka; Anita Kornicka; Anna Kuchnio; Maike Heinrichs; Renate Gruen 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views