Synthesis of a Novel Series of 2,3-Disubstituted Quinazolin-4(3H)-ones as a Product of a Nucleophilic Attack at C(2) of the Corresponding 4H-3,1-Benzoxazin-4-one

✍ Scribed by Mahr A. El-Hashash; Yaser A. El-Badry

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 182 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000230

✦ Synopsis

Abstract

A new series of 2,3‐disubstituted quinazolin‐4(3__H__)‐one derivatives was synthesized by nucleophilic attack at C(2) of the corresponding key starting material 2‐propyl‐4__H__‐3,1‐benzoxazin‐4‐one (Scheme 2). The reaction proceeded via amidinium salt formation (Scheme 3) rather than via an N‐acylanthranilimide. The structure of the prepared compounds were elucidated by physical and spectral data like FT‐IR, ^1^H‐NMR, and mass spectroscopy.