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Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic

✍ Scribed by Byoung J. Min; Xuyuan Gu; Takashi Yamamoto; Ravil R. Petrov; Hongchang Qu; Yeon Sun Lee; Victor J. Hruby

Book ID
108284846
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
231 KB
Volume
49
Category
Article
ISSN
0040-4039

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We describe the synthesis of benzyl (6S)-1, 3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from (S)-pyroglutamic acid as starting material.