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Synthesis of benzyl (6S)-1,3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative

✍ Scribed by Philippe Gloanec; Yolande Hervé; Nathalie Brémand; Jean-Pierre Lecouvé; Fabienne Bréard; Guillaume De Nanteuil

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 69 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00574-9

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✦ Synopsis

We describe the synthesis of benzyl (6S)-1, 3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from (S)-pyroglutamic acid as starting material.

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