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Synthesis of a novel 3, 4-dihydromilbemycin analogue.

✍ Scribed by Christine Greck; Peter Grice; A. Brian Jones; Steven V. Ley


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
164 KB
Volume
28
Category
Article
ISSN
0040-4039

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Synthesis of novel nucleosides of 4-oxoq
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A series of new ribonucleosides 1a-d having 4-oxoquinoline-3-carboxylic acid substituted with a chloro or bromo atom in the aromatic ring, as the nitrogen base, was synthesized and examined for anti-HIV activity. Compounds 1a and 1c showed a modest inhibition activity on HIV-1 reverse transcriptase,