Synthesis of novel nucleosides of 4-oxoquinoline-3-carboxylic acid analogues

✍ Scribed by Anderson D. da Matta; Carla Verônica B. dos Santos; Helena de S. Pereira; Izabel Christina de P. P. Frugulhetti; Mara Rita P. de Oliveira; Maria Cecília B. V. de Souza; Nissan Moussatché; Vitor F. Ferreira

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 150 KB
• Volume: 10
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/(sici)1098-1071(1999)10:3<197::aid-hc4>3.0.co;2-z

✦ Synopsis

A series of new ribonucleosides 1a-d having 4-oxoquinoline-3-carboxylic acid substituted with a chloro or bromo atom in the aromatic ring, as the nitrogen base, was synthesized and examined for anti-HIV activity. Compounds 1a and 1c showed a modest inhibition activity on HIV-1 reverse transcriptase, inhibiting 10% of the enzyme activity at the concentration of 100 lM.