4′-Methyloxycarbamyl-3′-deoxy-5-methyluridine; synthesis of a novel nucleoside analogue
✍ Scribed by Lea Pickering; Baljinder S Malhi; Paul L Coe; Richard T Walker
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 550 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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A series of new ribonucleosides 1a-d having 4-oxoquinoline-3-carboxylic acid substituted with a chloro or bromo atom in the aromatic ring, as the nitrogen base, was synthesized and examined for anti-HIV activity. Compounds 1a and 1c showed a modest inhibition activity on HIV-1 reverse transcriptase,
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