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Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase

✍ Scribed by Kamil Kuča; Jiřı́ Bielavský; Jiřı́ Cabal; Jiřı́ Kassa


Book ID
104364069
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
139 KB
Volume
13
Category
Article
ISSN
0960-894X

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✍ Kamil Kuca; Jiri Cabal; Kamil Musilek; Daniel Jun; Jiri Bajgar 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

Two cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun-inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI-6) were practically without react