Effective bisquaternary reactivators of tabun-inhibited AChE

✍ Scribed by Kamil Kuca; Jiri Cabal; Kamil Musilek; Daniel Jun; Jiri Bajgar

• Book ID: 102292039
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 126 KB
• Volume: 25
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.1084

✦ Synopsis

Two cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun-inhibited acetylcholinesterase of the rat brain was tested in vitro. Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI-6) were practically without reactivation potency. On the other hand, oximes K074, K075 and trimedoxime were satisfactorily effective. Moreover, K-oximes reactivated tabun-inhibited AChE at lower concentration (10(-4) and 10(-3) m) in comparison with trimedoxime (10(-3) and 10(-2) m). Thus, K-oximes can be considered as the most effective reactivators of tabun-inhibited AChE at present.