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In vitro comparison of eight acetylcholinesterase reactivators to reactivate VX inhibited ACHE

✍ Scribed by Daniel Jun; Jiri Bajgar; Kamil Kuca

Book ID
119378611
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
69 KB
Volume
164
Category
Article
ISSN
0378-4274

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## Abstract Nine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromid

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In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and HlΓΆ-7) for reactivation of sarin-and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All o