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In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions

✍ Scribed by Kamil Kuca; Jiri Cabal; Daniel Jun; Jiri Kassa; Lucie Bartosová; Gabriela Kunesová

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 136 KB
Volume: 25
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.1065

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✦ Synopsis

In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI-6, trimedoxime, BI-6 and Hlö-7) for reactivation of sarin-and cyclosarin-inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin-inhibited AChE. On the other hand, only HI-6 is able to reactivate satisfactorily cyclosarin-inhibited AChE.

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Comparison of in vitro potency of oximes

Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain

✍ Kamil Kuca; Jiri Cabal; Jiri Kassa; Daniel Jun; Martina Hrabinová 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

The potency of currently used oximes to reactivate sarin-inhibited acetylcholinesterase (AChE) in various parts of pig brain and whole pig brain was evaluated using in vitro methods. Significant differences in reactivation potency among all tested oximes were observed. At concentrations (10 - ----4