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Synthesis of a key intermediate for Thienamycin and Imipenem through stereoselective two-direction elongation of asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA∗)

✍ Scribed by Luca Banfi; Giuseppe Guanti; Maria Teresa Zannetti


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
250 KB
Volume
37
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES


Convergent synthesis of a key intermedia
✍ Giuseppe Guanti; Luca Banfi; Giovanna Schmid 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 296 KB

## 16132 GENOVA (Italy) .4bxhu& Compound 2, which is a known intermediate for the total synthesis of hypocholesterolemic agent 1233A 1, has been synthesized in good overall yield through a convergent approach, employing 3-hydroxy-2-methylpropanoate 6 and BHYMA\* 5 as chiral building blocks.