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Chemoenzymatic preparation of a key intermediate for carbapenem synthesis starting from asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*)

โœ Scribed by Luca Banfi; Giuseppe Guanti; Enrica Narisano

Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
710 KB
Volume
49
Category
Article
ISSN
0040-4020

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๐Ÿ“œ SIMILAR VOLUMES

Convergent synthesis of a key intermedia
Convergent synthesis of a key intermediate for hypocholesterolemic agent 1233A, starting from methyl 3-hydroxy-2-methylpropanoate and asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*)
โœ Giuseppe Guanti; Luca Banfi; Giovanna Schmid ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 296 KB

## 16132 GENOVA (Italy) .4bxhu& Compound 2, which is a known intermediate for the total synthesis of hypocholesterolemic agent 1233A 1, has been synthesized in good overall yield through a convergent approach, employing 3-hydroxy-2-methylpropanoate 6 and BHYMA\* 5 as chiral building blocks.