Convergent synthesis of a key intermediate for hypocholesterolemic agent 1233A, starting from methyl 3-hydroxy-2-methylpropanoate and asymmetrized bis(hydroxymethyl)acetaldehyde (BHYMA*)

✍ Scribed by Giuseppe Guanti; Luca Banfi; Giovanna Schmid

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 296 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73162-5

✦ Synopsis

16132 GENOVA (Italy)

.4bxhu& Compound 2, which is a known intermediate for the total synthesis of hypocholesterolemic agent 1233A 1, has been synthesized in good overall yield through a convergent approach, employing 3-hydroxy-2-methylpropanoate 6 and BHYMA* 5 as chiral building blocks.