✦ LIBER ✦

Synthesis of a key intermediate for the total synthesis of streptovaricin A

✍ Scribed by Peter A. McCarthy

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 237 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88703-1

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✦ Synopsis

A key intermediate ( ) in its optically active form. P for the total synthesis of streptovaricin A (A) is synthesized urther elaboration of 2 is also described.

Streptovaricin A (J,), produced by Streptomyces spectabilis, is an ansamycin antibiotic with notable antitumor activity.

1 The streptovaricins were first isolated by Siminoff and co-workers in 1957* and the structures were elucidated by Rinehart and co-workers in the early seventies. 3

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