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Synthesis of a chiral di(hydroxyalkyl) substituted bicyclic guanidine

✍ Scribed by Ingo Münster; Ulrike Rolle; Annemieke Madder; Pierre J. De Clercq

Book ID
103977298
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
128 KB
Volume
6
Category
Article
ISSN
0957-4166

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✦ Synopsis

Schmidtchen's methodology is used successfully for the synthesis of the chiral disubstituted bicyclic guanidinium salt 2. The two therefore required primary amine compounds 6 and 9 are obtained from L-methionine and L-glutamic acid, respectively.

📜 SIMILAR VOLUMES

ChemInform Abstract: The Synthesis of Di
ChemInform Abstract: The Synthesis of Di(hydroxyalkyl) Substituted Bicyclic Guanidines.
✍ A. MADDER; I. MUENSTER; U. ROLLE; P. J. DE CLERCQ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

The Synthesis of Di(hydroxyalkyl) Substituted Bicyclic Guanidines. -The enantiomerically pure guanidine (XIII) is synthesized by a route based on a methodology developed by Schmidtchen for bicyclic guanidines containing two differently protected hydroxyalkyl side chains. The desired intermediate (X

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