The synthesis of 4-amino-7-(8-D-ribofuranosyl)-furoC3.2-dlpyrimidine, a new Cnucleoside analog of adenosine. is described. It involves base-catalyzed cyclization of the 2-(ribofuranosyl)-t-cyan0 ethers 3 to afford the ribosyl-3-amino-2-cyanofurans 4a and 48. followed by a two step conversion into th
✦ LIBER ✦
Synthesis of “9-deazaadenosine”; A new cytotoxic C-nucleoside isostere of adenosine
✍ Scribed by Mu-Ill Lim; Robert S. Klein
- Book ID
- 107858292
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 221 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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The first synthesis of M , the pyrrolo[2,1-fl[1.2,4]triazinc C-nucleoside congener of adenosine is described. The key intexmediate ribofuranosyl pyrmle 4 is obtained by the direct C-ribosylation of pyrrolemagnesiumbromide with 2,3,5-t& 0-benzyl ribose followed by an acid-catalyzed dehydration. Vilsm
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