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Synthesis of 1,N 6 -etheno-2-aza-adenosine (2-aza-ε-adenosine): a new cytotoxic fluorescent nucleoside

✍ Scribed by Tsou, K.C.; Yip, K.F.; Miller, E.E.; Lo, K.W.


Book ID
126919313
Publisher
Oxford University Press
Year
1974
Tongue
English
Weight
419 KB
Volume
1
Category
Article
ISSN
0305-1048

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1,N6-etheno-2-aza-adenosine 3′,5′-monoph
✍ K.C. Tsou; K.F. Yip; K.W. Lo 📂 Article 📅 1974 🏛 Elsevier Science 🌐 English ⚖ 369 KB

I,N"-etheno-2-aza-adenosine 3',5'-monophosphate (cyclic Z-aza+AMP) has been shown to be a sensitive and an efficient substrate for the assay of cyclic-nucleotide phosphodiesterase. The relative activity is 75% compared to cyclic AMP. Two K, values of 503 and 15 pM were observed with the beef heart e