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Synthesis of 8-substituted derivatives of the 2-deoxy analog of 3-deoxy-.beta.-D-manno-2-octulopyranosonic acid (2-deoxy-.beta.-KDO) as inhibitors of 3-deoxy-D-manno-octulosonate cytidylyltransferase

✍ Scribed by Pring, Brian G.; Jansson, Anita M.; Persson, Kerstin; Andersson, Inger; Gagner-Milchert, Ingalill; Gustafsson, Kent; Claesson, Alf


Book ID
127272417
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
885 KB
Volume
32
Category
Article
ISSN
0022-2623

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Synthesis of 3-deoxy-D-manno-2-octuloson
✍ Frick, Wendelin ;KrΓΌlle, Thomas ;Schmidt, Richard R. πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 423 KB

## Abstract [(Benzyloxy)(benzyloxycarbonyl)methyl]triphenylphosphonium bromide (8), obtained from glyoxylic acid via a convenient one‐pot procedure, reacted in a Wittig reaction with 4‐__O__‐benzyl‐2,3:5,6‐di‐__O__‐isopropylidene‐D‐mannose (7), readily synthesized on a large scale from D‐mannose, t