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Synthesis of 8-chloro-6-phenyl-4H-s-triazolo [4,3-a] [1,4] benzo-diazepine-1-14C

✍ Scribed by Nobuyoshi Hayashi; Kazuo Shinozaki; Shinji Kato; Kanji Meguro; Yutaka Kuwada

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
155 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

8‐Chloro‐6‐phenyl‐4H‐s‐triazolo [4,3‐a] [1,4] benzodiazepine (D‐40TA)‐1‐^14^C (V‐^14^C) was synthesized by the reaction of formic acid‐^14^C with 7‐chloro‐2‐hydrazino‐5‐phenyl‐3H‐1, 4‐benzodiazepine in the presence of N,N′‐carbonylbis (2‐methylimidazole). The overall radio‐chemical yield from formic acid‐^14^C was 57.8%.

📜 SIMILAR VOLUMES

Synthesis of carbon-14 labeled 1,4-benzo
Synthesis of carbon-14 labeled 1,4-benzodiazepines. III. 2-allyloxy-amino-7-chloro-5-(2-chlorophenyl)-3h-l,4-benzodiazepine-2-14C, 8-chloro-1-dimethylamino-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-3a-14C, and 8-chloro-2,4-dihydro-2-methyl-6-phenyl-1H-s-triazolo[4,3-a] [1,4]benzodiazepin-l-one-3a-14
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Synthesis of carbon-14 labeled 1,4-benzo
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## Abstract ^14^C‐Labelled (S)‐(+)‐6‐(2‐chlorophenyl)‐3‐cyclopropanecarbonyl‐8,11‐dimethyl‐2,3,4,5‐ tetrahydro‐8H‐pyrido[4′,3′:4,5]thieno[3,2‐f][1,2,4]triazolo[4,3‐a][1,4] diazepine (^14^C‐E6123), a platelet activating factor receptor antagonist for studying the pharmacokinetic profile of E6123, wa

Syntheses of 7-phenyl-5h-thiazolo[5,4-e]
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✍ A. Shafiee; M. Shekarchi 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 48 KB 👁 1 views

## Abstract Fused tricyclic 7‐phenyl‐5__H__‐thizolo[5,4‐__e__]pyrrolo[1,2‐__a__][1,4]diazepin‐10(9__H__)one (**10**) was prepared by thermolysis of 2‐phenyl‐4‐(1‐pyrrolylmethyl)thiazole‐5‐carbonyl azide (**9**) in acetic acid. In addition, starting from **10**, 7‐phenyl‐5__H__‐thiazolo [5,4‐__e__][