𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 7a-substituted benzoylaminoalkyl-hexahydro-1H-pyrrolizines and evaluation of their antiarrhythmic activity

✍ Scribed by Seiji Miyano; Keiyu Shima; Mariko Hayashimatsu; Fumio Satoh; Kunihiro Sumoto

Book ID
102408799
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
276 KB
Volume
76
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

Several 7a-substituted benzoylaminoalkyl-hexahydro-1 H-pyrrolizines were synthesized by acylations of 7a-aminoalkyl-hexahydro-1 H-pyrrolizines. All compounds synthesized were evaluated for their antiarrhythmic activities using the chloroform-mouse method, and some of them were found to have significant antiarrhythmic activities, comparable to that of procainamide.

πŸ“œ SIMILAR VOLUMES

Facile Synthesis of Diastereoisomericall
Facile Synthesis of Diastereoisomerically and Optically Pure 2-Substituted Hexahydro-1H-pyrrolizin-3-ones
✍ Romain Siegrist; Corinne Baumgartner; Paul Seiler; FranΓ§ois Diederich πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 German βš– 160 KB

We report a short synthetic route that provides optically active 2-substituted hexahydro-1H-pyrrolizin-3ones in four steps from commercially available Boc (tert-but(oxy)carbonyl))-protected proline. Diastereoisomers (Γ€)-11 and (Γ€)-12 were assembled from the proline-derived aldehyde (Γ€)-8 and ylide 9