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Synthesis and antileukemic activity of 5-substituted 2,3-dihydro-6,7-bis(hydroxymethyl)-1H-pyrrolizine diesters

✍ Scribed by Anderson, Wayne K.; Corey, Paul F.


Book ID
126947034
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
836 KB
Volume
20
Category
Article
ISSN
0022-2623

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## Abstract The title compound 4 is synthesized in 8 steps by cyclization of __N__‐tosylglycinate 5 with vinyl ketone 6. After elimination of water and sulfinic acid the pyrrolecarboxylate 9 is obtained which, on __N__‐alkylation with ethyl acrylate, Dieckmann cyclization, saponification and decarb