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Synthesis of [7,7-2H2]epibrassinolide

✍ Scribed by Vladimir A. Khripach; Natalya B. Khripach; Vladimir N. Zhabinskii; Yuliya Y. Zhiburtovich; Bernd Schneider; Aede de Groot

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
121 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Synthesis of labelled epibrassinolide containing two deuterium atoms in a position which is not subjected to isotopic exchange is reported. Key transformations include preparation of 6,7‐seco steroidal diacid, its cyclization to a cyclic anhydride followed by a regioselective reduction with NaBD~4~. The obtained [7,7‐^2^H~2~]epibrassinolide can be used in biochemical experiments when the loss of isotopic label should be avoided. Copyright © 2007 John Wiley & Sons, Ltd.

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