## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid
Synthesis of 7-[α-(2-aminothiazol-4-yl)-α-(z)-methoximinoacetamido]-3-(1-[14C]methylpyrrolidinio)-methyl-3-cephem-4-carboxylate sulfate
✍ Scribed by J. E. Swigor; K. K. Pittman
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- French
- Weight
- 266 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
1-(Cyclohexyloxycarbony1oxy)ethyl 7P-[2-(2-aminothiazol-~-yl~acetamido]-3-[[[1-(2-dimethylaminoethyl~-1H-tetrazol-~-yl]thio]methyl]ceph-3-em-4-carboxylate dihydrochloride (SCE-2174), a new orally active cephalos orin, was labeled with carbon-14 starting from [l-lgC] c yc lohexanol (1) . 1 -Chloroe t
Cefamandole, 7-D-mandelamino-3-{ [(l-methyl-lH-tetrazo1-5-yl)-thio]methyl}-3-cephem-4-carboxylic acid (I), is a new semisynthetic, parenteral cephalosporin antibiotic with a broad antibacterial spectrum, synthesized by the Lilly Research Laboratories.
## Abstract (6R,7R)‐7‐[2‐(5‐amino‐1,2,4‐thiadiazol‐3‐yl)‐(Z)‐2‐methoxyiminoacetamido]‐3‐[4‐(carbamoyl‐1‐quinuclidinio)methyl]ceph‐3‐em‐4‐carboxylate (E1040), a new injectable cephalosporin with potent antipseudomonal activity, was synthesized labelled with carbon‐14, starting from potassium [^14^C]
Syn thes is of 14C -labe 1 led 4 -chloro -3 -s u l f amoyl -N -(3aa, 4a, 5 , 6 7a,7aa-hexahydro-4,7-methano-isoindolin-Z-yl)-benzamide.