Synthesis of 7-oxo-3-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylates: analogues of clavulanic acid
β Scribed by Brennan, John; Richardson, Geoffrey; Stoodley, Richard J.
- Book ID
- 115509932
- Publisher
- The Royal Society of Chemistry
- Year
- 1980
- Tongue
- English
- Weight
- 150 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0022-4936
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The title compound was prepared in good yield via intramolecular insertion of an a-alkoxycarbonyl, a-sulphonyl carbene into the N-H bond of an azetidinone. Esters of (k) 7-oxo-3-thia-l-azabicyclo[3.2.0lheptane-2-carboxylate-3,3-dioxide, 1, are potentially useful intermediates in the synthesis of no
A novel, high yield synthesis of the l-carbapenam ring system J, is described in which the entire carbon framework is introduced in a single step from simple precursors. Thienamycin (A) and clavulanic acid (L), new naturally occurring B-lactams