✦ LIBER ✦

A facile synthesis of benzyl 3,7-dioxo-1-azabicyclo[3.2.0]Heptane-2-carboxylate. A potential precursor of thienamycin and clavulanic acid analogs

✍ Scribed by D.A. Berges; E.R. Snipes; G.W. Chan; W.D. Kingsbury; C.M. Kinzig

Publisher: Elsevier Science
Year: 1981
Tongue: French
Weight: 198 KB
Volume: 22
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81957-2

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✦ Synopsis

A novel, high yield synthesis of the l-carbapenam ring system J, is described in which the entire carbon framework is introduced in a single step from simple precursors.

Thienamycin (A) and clavulanic acid (L), new naturally occurring B-lactams

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