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Synthesis of 7-Deamidocephalosporin Lactone. Preliminary Communication

✍ Scribed by Gérard Schmid; Kapa K. Prasad; Theodor Petrzilka

Publisher
John Wiley and Sons
Year
1976
Tongue
German
Weight
290 KB
Volume
59
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Condensation of azetidinone 1 with mercaptan 3 gave compound 5. Bromination of 5 afforded two isomeric bromohydrins 11a and 11b which differ in the configuration at C(4). Acetylation and reduction with zinc and acetic acid of the above bromohydrins gave 7‐deamidocephalosporin lactone (14).

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