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Synthesis of 6-(2-hydroxybenzoyl)pyrazolo[1,5-a]pyrimidines by reaction of 5-amino-1h-pyrazoles and 3-formylchromone

✍ Scribed by Jairo Quiroga; Diana Mejía; Braulio Insuasty; Rodrigo Abonía; Manuel Nogueras; Adolfo Sánchez; Justo Cobo; J. N. Low

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
41 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Reaction of 3‐formylchromone (1) with 5‐amino‐1__H__‐pyrazoles (2) in ethanol, afforded 6‐(2‐hydroxy‐benzoyl)pyrazolo[1,5‐a]pyrimidines (3a‐g) in good yields. The structures and the regiospecificity of the reaction were established by nmr measurements and X‐ray analysis, in which soft intermolecular hydrogen‐bonded networks were found.

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