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Design and synthesis of novel sulfone-containing pyrazolo[1,5-a]-pyrimidines and pyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones

✍ Scribed by Yan-Chao Wu; Xiao-Mao Zou; Fang-Zhong Hu; Hua-Zheng Yang

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 63 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420421

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✦ Synopsis

A series of novel sulfone-containing pyrazolo [1,5-a] pyrimidines (2-3) andpyrazolo[5,1-d][1,2,3,5]tetrazine-4(3H)-ones (5a-5k) were designed and efficiently synthesized, some of which have been identified as being potential rape inhibitors. These results widen the structural diversity of rape inhibitors and confirm the perspectives of further investigations in this area. Moreover, a plausible reaction mechanism is outlined.

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