## Abstract We report the synthesis of [6โ^15^N]โlabeledโAMP following a novel route from adenosine with an overall yield (12%) better than with a previously described procedure from inosine (6%). The two analogues of [6โ^15^N]โadenosine triphosphate, adenylyl imidodiphosphate (AMPโPNP) and adenyly
Synthesis of 6-15N and 1-15N labeled adenosine monophosphates
โ Scribed by Simon R. Sarfati; Vinod K. Kansal
- Book ID
- 104204963
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 492 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
## Abstract The synthesis of ^15^Nโlabelled nornicotine **2** and ^15^Nโlabelled nicotine **1** is described via the reductive aminocyclization of a 1,4โketoaldehyde with a corresponding amine in the presence of sodium cyanoborohydride. Yields of 30% and 26%, respectively, were obtained from 3โbrom
The synthesis of 15N labelled nylon 6 by anionic polymerization of Ecaprolactam is described. Labelling of this commercially important polymer should greatly enhance investigations of its morphology by techniques such as NMR, IR, and Raman spectroscopies.
Coniine-15N was obtained by the reductive amination of 5-0x0octanal using sodium cyanoborohydride and a m m o n i ~m -~~N bromide. Nornicotine-l'-15N resulted from a similar reductive aminution of 4-oxo-4-(3'-pyridyl)butanal. Merhybtion with formaldehyde and ,formic acid afforded n i ~o t i n e -I '