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Isotopically labelled adenosine triphosphate analogues: Synthesis of [6-15N]- adenylyl imidodiphosphate and [6-15N]-adenylyl methylenediphosphonate

✍ Scribed by S. R. Sarfati; S. Pochet

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 365 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580291209

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✦ Synopsis

Abstract

We report the synthesis of [6‐^15^N]‐labeled‐AMP following a novel route from adenosine with an overall yield (12%) better than with a previously described procedure from inosine (6%). The two analogues of [6‐^15^N]‐adenosine triphosphate, adenylyl imidodiphosphate (AMP‐PNP) and adenylyl methylenediphosphonate (AMP‐PCP), were prepared from labeled AMP.

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