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Synthesis of (5′S)-[5′-2H1;1′,2′,3′,4′,5′-13C5]-Thymidine via stereoselective deuteration of a 5-oxoribose derivative

✍ Scribed by Akira (Mei) Ono; Akira Ono; Masatsune Kainosho

Book ID
104256027
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
284 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

transfer reaction fmm (-)-or (+)-[2-'H,]-isobomyloxymagnesium bmmide to a 5-oxoribose derivative., which can be readily prepared hum ['3C,]-D-glucose. The overall yield from D-glucose to thymidine wig 27%. The various nucleosides with tt stereoselective 'H-label together with "C at the C5' position, which have become available by the present method. will be quite useful for stereospecific assignment of the diasterwtopic C5' metbylette signals. and also for conformational analyses of the OS'CS' bonds in nucleic acid oligomers.

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