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Synthesis of (5R,10S,11R)-(+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imin-11-ol: a hydroxylated metabolite of MK-0801

โœ Scribed by Larsen, Robert D.; Davis, Paul; Corley, Edward G.; Reider, Paul J.; Lamanec, Theresa Rothauser; Grabowski, Edward J. J.


Book ID
126890583
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
911 KB
Volume
55
Category
Article
ISSN
0022-3263

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Synthesis of 11C-labeled (ยฑ)-5-methyl-10
โœ Dale O. Kiesewetter; Ronald D. Finn; Kenner C. Rice; James A. Monn ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science โš– 367 KB

The synthesis of C5 labeled (+-)-5-[11C]methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten- 5,10-imine [(+-)-[11C]MK801] has been accomplished via alkylation of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine-N-t- butylformamidine [(+-)-5-des-methyl MK801 formamidine). The 11C labeling is ac