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Synthesis of 11C-labeled (±)-5-methyl-10, 11-dihydro-5H-dibenzo[a,d]cyclohepten-5, 10-imine [(±)-[11C]MK801]

✍ Scribed by Dale O. Kiesewetter; Ronald D. Finn; Kenner C. Rice; James A. Monn

Book ID: 103922395
Publisher: Elsevier Science
Year: 1990
Weight: 367 KB
Volume: 41
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(90)90098-2

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✦ Synopsis

The synthesis of C5 labeled (+-)-5-[11C]methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten- 5,10-imine [(+-)-[11C]MK801] has been accomplished via alkylation of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine-N-t- butylformamidine [(+-)-5-des-methyl MK801 formamidine). The 11C labeling is accomplished by reaction of the anion of (+-)-5-des-methyl MK801 formamidine, generated with s-butyllithium, and [11C]methyl iodide.

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