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Synthesis of 5-(β-D-glucopyranosyloxymethyl)-2′-deoxyuridine and derivatives thereof. A modified d-nucleoside from the DNA of Trypanosoma brucei

✍ Scribed by E. R. Wijsman; O. van den Berg; E. Kuyl-Yeheskiely; G. A. van der Marel; J. H. van Boom

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
198 KB
Volume
113
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

An appropriately protected 3′‐phosphoramidite and 5′‐phosphate derivative of the modified 2′‐deoxyuridine were obtained by β‐glycosylation of a properly protected 5‐hydroxymethyl‐2′‐deoxyuridine, and subsequent elaboration of the resulting intermediates using standard protocols devised in nucleic acids chemistry.

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